Mercedes-Benz E350 4matic
2006–2026 · 24 configurations
The Mercedes-Benz E350 4matic has been tested by the EPA across 24 different configurations spanning model years 2006 through 2026. Over this period, the E350 4matic has achieved combined fuel economy ratings ranging from 18 MPG to 27 MPG, with an overall average of 22 MPG across all engine, transmission, and drivetrain combinations. Below you will find a comprehensive breakdown of every tested configuration, organized by model year. Click any row to view detailed specifications, emissions data, and annual fuel cost estimates for that specific vehicle.
All Configurations
Historical Efficiency
Safety Rating History
NHTSA typically tests the base platform of a vehicle and does not test every specific trim level. This specific configuration (E350 4matic) has not been independently rated.
Complaint & Incident History
The data below represents all official consumer complaints reported to the National Highway Traffic Safety Administration (NHTSA) for the Mercedes-Benz E350 4matic. Click on any year to drill down and read the unedited, raw problem narratives submitted directly by vehicle owners.
Platform Recall Intelligence
Most Recalled Components
Tip: Click any component bar to view detailed recall narratives.