Mercedes-Benz E350
2006–2026 · 23 configurations
The Mercedes-Benz E350 has been tested by the EPA across 23 different configurations spanning model years 2006 through 2026. Over this period, the E350 has achieved combined fuel economy ratings ranging from 19 MPG to 28 MPG, with an overall average of 23 MPG across all engine, transmission, and drivetrain combinations. Below you will find a comprehensive breakdown of every tested configuration, organized by model year. Click any row to view detailed specifications, emissions data, and annual fuel cost estimates for that specific vehicle.
All Configurations
Historical Efficiency
Safety Rating History
NHTSA typically tests the base platform of a vehicle and does not test every specific trim level. This specific configuration (E350) has not been independently rated.
Complaint & Incident History
The data below represents all official consumer complaints reported to the National Highway Traffic Safety Administration (NHTSA) for the Mercedes-Benz E350. Click on any year to drill down and read the unedited, raw problem narratives submitted directly by vehicle owners.
Platform Recall Intelligence
Most Recalled Components
Tip: Click any component bar to view detailed recall narratives.