2022 Lexus IS 350 AWD
Fuel Economy Overview
The 2022 Lexus IS 350 AWD achieves an EPA-estimated 22 MPG in combined city and highway driving, with 19 MPG in the city and 26 MPG on the highway. Powered by a 3.5L 6-cylinder engine paired with a automatic (s6), this compact cars features All-Wheel Drive drive.
In terms of environmental impact, the 2022 IS 350 AWD produces approximately 407 grams of CO2 per mile. This figure is measured under standardized EPA test conditions and represents tailpipe emissions only. For context, the average new vehicle sold in the United States produces approximately 400 grams of CO2 per mile, meaning this IS 350 AWD has higher-than-average emissions in this regard.
The estimated annual fuel cost for this vehicle is $3,150, based on 15,000 miles of driving per year and current national average fuel prices. Compared to the average new vehicle, you would save $5,000 over a 5-year period. This calculation accounts for differences in fuel consumption efficiency and provides a practical measure of long-term ownership costs attributable to fuel economy.
Energy DNA
Green Scorecard
Personalized Commute CalculatorEPA defaults to 55% City / 45% Hwy
Adjust the slider to match your daily driving habits. City driving involves stop-and-go traffic under 45mph, while highway driving represents sustained speeds over 55mph.
Aerodynamic Speed Penalty
EPA highway tests average roughly 48 mph. Driving at 75 mph increases aerodynamic drag exponentially. Expect your real-world highway fuel economy to drop by roughly 15-20% at interstate speeds.
5-Year Total Cost of Ownership
Recall Intelligence
Toyota Motor Engineering & Manufacturing (Toyota) is recalling certain 2015-2022 Lexus RC, 2016-2020 GS, and 2022 IS vehicles. The low-pressure fuel pump inside the fuel tank may fail.
Consequence & Remedy
Consequence: Fuel pump failure can cause an engine stall, increasing the risk of a crash.
Remedy: Dealers will replace the fuel pump assembly, free of charge. Owner notification letters are expected to be mailed June 8, 2026. Owners may contact Toyota's customer service at 1-800-331-4331. Toyota's numbers for this recall are 26LB05 and 26LA05.
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Looking for comprehensive historical data?
NHTSA FARS (Fatal Crash History) and broader generational safety trends are aggregated at the model level rather than by specific engine configurations. View the complete historical data profile for all Lexus IS 350 AWD configurations.
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Fuel Cost Analysis
Based on 15,000 miles/year and current fuel prices.
Efficiency Breakdown
Estimated Lifetime Carbon Footprint
(Based on 200,000 miles driven)